Haya Therapeutics SA

Conditions of employment: Eligible to work in U.S. (U.S. citizenship or work permit/authorization) Salary range: $190,000-$250,000 per year, depending on experience. Reports To: Chief Medical Officer (CMO) Department: Clinical Development Travel: up to 50% Why us Be part of a team pioneering cutting-edge research at the forefront of precision medicine Collaborate with a dynamic and innovative team of scientists in a fast-paced biotech environment Competitive benefits package If you believe you are a strong fit for this position, please apply today! To Apply: Please email your CV to E-Mail schreiben and include "A_MD" in the subject line to indicate the position for which you are applying. Position Summary HAYA Therapeutics is seeking a Senior Medical Director, Cardiovascular Medicine, and Clinical Development to lead the clinical development execution for HAYA’s lead asset in Hypertrophic Cardiomyopathy (HCM). In this highly visible and impactful role, you will execute the clinical strategy and oversee the development of innovative Antisense Oligonucleotide (ASO) targeting novel therapeutic approaches for HCM. This includes leading early-phase clinical studies and integrating precision RNA medicine into clinical trial design. You will collaborate closely with executive leadership, the preclinical research team, and external partners to advance HCM therapeutics through all stages of clinical development. As Senior Medical Director, you will collaborate with multidisciplinary teams to develop novel treatments, providing first-in-biology solutions for patients suffering from HCM and cardiomyopathies more broadly. What’s in it for me? In this leadership role, you’ll have the rare opportunity to be at the forefront as the clinical development function is being established. As the first in this position, you will partner closely with the CMO, providing input and insights as the function takes shape while playing a pivotal role in executing clinical development plans to advance HAYA’s lead asset. You’ll tackle key challenges in cardiovascular medicine by leading early-phase clinical studies and integrating precision RNA medicine into trial design. Reporting directly to the CMO, you’ll drive the execution of clinical trials while collaborating with a high-performing team to advance cutting-edge therapeutics. If you're a problem solver, this role is for you. You will address challenges in clinical protocol development, study execution, data monitoring, and regulatory compliance while advancing RNA therapeutics for HCM and other cardiovascular conditions to transform patient outcomes. Joining HAYA means being part of an innovative, collaborative team dedicated to pioneering treatments that will reshape the clinical landscape and improve the lives of patients suffering from HCM and related cardiovascular conditions. Key Responsibilities: Therapeutic Area and Leadership: Serve as Senior Medical Director for hypertrophic cardiomyopathy (HCM), executing the clinical strategy for Antisense Oligonucleotide RNA-based therapeutics and precision RNA medicine. Lead the integration of learning from precision RNA science and translational studies into clinical development execution, working closely with leading RNA scientists, biomarker discovery, and patient stratification to enable personalized treatment approaches for HCM. Collaborate with cross-functional teams to drive the clinical HCM RNA therapeutics portfolio, ensuring the program aligns with the company’s strategic goals and scientific objectives. Oversee the execution of clinical plans incorporating cutting-edge RNA technologies, ensuring the development of innovative RNA-based therapeutics for HCM. Clinical Development & Medical Oversight: Oversee clinical trial design, contributing to developing clinical protocols and ensuring precision RNA medicine is embedded in trial designs, endpoints, and methodologies. Serve as the medical lead and medical monitor for early-phase studies, including first-in-human trials, and ensure rigorous safety and efficacy evaluations for RNA-based therapeutics. Work closely and cross-functionally on developing and validating biomarkers, including RNA-based biomarkers, genomic profiling, proteomics, and imaging technologies, to monitor disease progression and therapeutic response. Ensure regulatory submissions for clinical trials meet FDA, EMA, and ICH guidelines and provide medical input into IND/CTA filings and other key clinical documentation. Cross-Functional Leadership & Collaboration: Collaborate with HAYA’s internal preclinical teams, clinical operations, biomarker discovery, and regulatory affairs to ensure the clinical development strategy is aligned with broader company goals. Provide expertise in RNA therapeutics and HCM clinical development by leading or participating in clinical advisory boards, steering committees, and data safety monitoring boards (DSMBs). Work closely with key opinion leaders (KOLs) and external experts to validate clinical strategies and ensure scientific excellence. Review and synthesize scientific literature on RNA therapeutics, HCM, and precision medicine, sharing insights across the company to inform ongoing and future development activities. Regulatory Strategy & Clinical Documentation: Contribute to regulatory strategy by ensuring alignment with regulatory agencies, including the FDA, EMA, and other global regulatory bodies, for HAYA's pipeline assets. Support the preparation and review of regulatory and trial document submissions related to HAYA’s pipeline of RNA-targeting therapies, including IND/CTA filings, clinical trial applications, and other necessary documentation. Education & Experience: MD or MD/PhD focusing on cardiovascular clinical development, RNA therapeutics, or a related field. A minimum of 10 years of experience in basic and/or translational science in cardiovascular medicine and therapeutics, with substantial experience in hypertrophic cardiomyopathy or related diseases. Proven experience in leading therapeutic area or asset-level clinical development programs, particularly focusing on Genetic Medicines/Therapies or RNA-based drug discovery. Board Certification (or equivalent) or substantial experience in Cardiovascular Diseases, Advanced Heart Failure, Familial/Genetic Cardiomyopathy, or Hypertrophic Cardiomyopathy is highly desirable. HAYA Therapeutics is an Equal Opportunity Employer committed to fostering a diverse, inclusive, and equitable workplace where all individuals feel valued and empowered. We provide equal employment opportunities to all qualified applicants and employees without regard to race, color, religion, sex (including pregnancy, sexual orientation, gender identity, or gender expression), national origin, ancestry, age, marital or familial status, veteran status, disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws. We prohibit discrimination and harassment of any kind and are committed to ensuring fair and equitable treatment in all aspects of recruitment, hiring, promotion, compensation, benefits, training, and career development. At HAYA, we believe that diversity of thought, experience, and background drives innovation and strengthens our mission to transform patient care through cutting-edge RNA-based therapeutics. HAYA Therapeutics is a precision RNA-based therapeutics company that discovers and develops innovative genomic medicines for the treatment of fibrosis and other serious health conditions associated with aging. The company’s discovery engine focuses on long non-coding RNAs (lncRNAs) within the “dark matter” of the human genome -- key tissue and cell-specific drivers of multiple disease processes including fibrosis -- to identify novel targets and drug candidates with the potential for greater efficacy and safety than existing treatments. Headquartered in Lausanne, Switzerland with laboratory facilities in San Diego, USA, HAYA is a rapidly growing company led by a world-class team and supported by a strong investor consortium.

Conditions of employment: Eligible to work in U.S. (U.S. citizenship or work permit/authorization) Salary range: $190,000-$250,000 per year, depending on experience. Reports To: Chief Medical Officer (CMO) Department: Clinical Development Travel: up to 50% Why us Be part of a team pioneering cutting-edge research at the forefront of precision medicine Collaborate with a dynamic and innovative team of scientists in a fast-paced biotech environment Competitive benefits package If you believe you are a strong fit for this position, please apply today! To Apply: Please email your CV to E-Mail schreiben and include "A_MD" in the subject line to indicate the position for which you are applying. Position Summary HAYA Therapeutics is seeking a Senior Medical Director, Cardiovascular Medicine, and Clinical Development to lead the clinical development execution for HAYA’s lead asset in Hypertrophic Cardiomyopathy (HCM). In this highly visible and impactful role, you will execute the clinical strategy and oversee the development of innovative Antisense Oligonucleotide (ASO) targeting novel therapeutic approaches for HCM. This includes leading early-phase clinical studies and integrating precision RNA medicine into clinical trial design. You will collaborate closely with executive leadership, the preclinical research team, and external partners to advance HCM therapeutics through all stages of clinical development. As Senior Medical Director, you will collaborate with multidisciplinary teams to develop novel treatments, providing first-in-biology solutions for patients suffering from HCM and cardiomyopathies more broadly. What’s in it for me? In this leadership role, you’ll have the rare opportunity to be at the forefront as the clinical development function is being established. As the first in this position, you will partner closely with the CMO, providing input and insights as the function takes shape while playing a pivotal role in executing clinical development plans to advance HAYA’s lead asset. You’ll tackle key challenges in cardiovascular medicine by leading early-phase clinical studies and integrating precision RNA medicine into trial design. Reporting directly to the CMO, you’ll drive the execution of clinical trials while collaborating with a high-performing team to advance cutting-edge therapeutics. If you're a problem solver, this role is for you. You will address challenges in clinical protocol development, study execution, data monitoring, and regulatory compliance while advancing RNA therapeutics for HCM and other cardiovascular conditions to transform patient outcomes. Joining HAYA means being part of an innovative, collaborative team dedicated to pioneering treatments that will reshape the clinical landscape and improve the lives of patients suffering from HCM and related cardiovascular conditions. Key Responsibilities: Therapeutic Area and Leadership: Serve as Senior Medical Director for hypertrophic cardiomyopathy (HCM), executing the clinical strategy for Antisense Oligonucleotide RNA-based therapeutics and precision RNA medicine. Lead the integration of learning from precision RNA science and translational studies into clinical development execution, working closely with leading RNA scientists, biomarker discovery, and patient stratification to enable personalized treatment approaches for HCM. Collaborate with cross-functional teams to drive the clinical HCM RNA therapeutics portfolio, ensuring the program aligns with the company’s strategic goals and scientific objectives. Oversee the execution of clinical plans incorporating cutting-edge RNA technologies, ensuring the development of innovative RNA-based therapeutics for HCM. Clinical Development & Medical Oversight: Oversee clinical trial design, contributing to developing clinical protocols and ensuring precision RNA medicine is embedded in trial designs, endpoints, and methodologies. Serve as the medical lead and medical monitor for early-phase studies, including first-in-human trials, and ensure rigorous safety and efficacy evaluations for RNA-based therapeutics. Work closely and cross-functionally on developing and validating biomarkers, including RNA-based biomarkers, genomic profiling, proteomics, and imaging technologies, to monitor disease progression and therapeutic response. Ensure regulatory submissions for clinical trials meet FDA, EMA, and ICH guidelines and provide medical input into IND/CTA filings and other key clinical documentation. Cross-Functional Leadership & Collaboration: Collaborate with HAYA’s internal preclinical teams, clinical operations, biomarker discovery, and regulatory affairs to ensure the clinical development strategy is aligned with broader company goals. Provide expertise in RNA therapeutics and HCM clinical development by leading or participating in clinical advisory boards, steering committees, and data safety monitoring boards (DSMBs). Work closely with key opinion leaders (KOLs) and external experts to validate clinical strategies and ensure scientific excellence. Review and synthesize scientific literature on RNA therapeutics, HCM, and precision medicine, sharing insights across the company to inform ongoing and future development activities. Regulatory Strategy & Clinical Documentation: Contribute to regulatory strategy by ensuring alignment with regulatory agencies, including the FDA, EMA, and other global regulatory bodies, for HAYA's pipeline assets. Support the preparation and review of regulatory and trial document submissions related to HAYA’s pipeline of RNA-targeting therapies, including IND/CTA filings, clinical trial applications, and other necessary documentation. Education & Experience: MD or MD/PhD focusing on cardiovascular clinical development, RNA therapeutics, or a related field. A minimum of 10 years of experience in basic and/or translational science in cardiovascular medicine and therapeutics, with substantial experience in hypertrophic cardiomyopathy or related diseases. Proven experience in leading therapeutic area or asset-level clinical development programs, particularly focusing on Genetic Medicines/Therapies or RNA-based drug discovery. Board Certification (or equivalent) or substantial experience in Cardiovascular Diseases, Advanced Heart Failure, Familial/Genetic Cardiomyopathy, or Hypertrophic Cardiomyopathy is highly desirable. HAYA Therapeutics is an Equal Opportunity Employer committed to fostering a diverse, inclusive, and equitable workplace where all individuals feel valued and empowered. We provide equal employment opportunities to all qualified applicants and employees without regard to race, color, religion, sex (including pregnancy, sexual orientation, gender identity, or gender expression), national origin, ancestry, age, marital or familial status, veteran status, disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws. We prohibit discrimination and harassment of any kind and are committed to ensuring fair and equitable treatment in all aspects of recruitment, hiring, promotion, compensation, benefits, training, and career development. At HAYA, we believe that diversity of thought, experience, and background drives innovation and strengthens our mission to transform patient care through cutting-edge RNA-based therapeutics. HAYA Therapeutics is a precision RNA-based therapeutics company that discovers and develops innovative genomic medicines for the treatment of fibrosis and other serious health conditions associated with aging. The company’s discovery engine focuses on long non-coding RNAs (lncRNAs) within the “dark matter” of the human genome -- key tissue and cell-specific drivers of multiple disease processes including fibrosis -- to identify novel targets and drug candidates with the potential for greater efficacy and safety than existing treatments. Headquartered in Lausanne, Switzerland with laboratory facilities in San Diego, USA, HAYA is a rapidly growing company led by a world-class team and supported by a strong investor consortium.

Conditions of employment: Eligible to work in U.S. (U.S. citizenship or work permit/authorization) Bachelor's Degree More than 4 years of professional experience in Primary Cells More than 4 years of professional experience in Genomics Salary range: 70 000 $US - 80 000 $US per year, depending on experience. Why us Be part of a team pioneering cutting-edge research at the forefront of precision medicine Collaborate with a dynamic and innovative team of scientists in a fast-paced biotech environment Competitive benefits package If you believe you are a strong fit for this position, please apply today! To Apply: Please email your CV to E-Mail schreiben and include the position for which you are applying in the subject line. Position Summary We are seeking a highly motivated Research Associate to support our preclinical research activities focused on musculoskeletal biology and cell culture. This role is critical in maintaining operational continuity and research efficiency. The successful candidate will play a key role in executing and optimizing laboratory workflows involving preclinical samples, with a strong emphasis on tissue handling, histology, and spatial transcriptomic. The Research Associate will provide hands-on expertise in core laboratory techniques, including cell culture, particularly in primary cells, as well as ASO screening (including GapmeRs and siRNA), multi-omics assays, and next-generation sequencing (NGS) technologies. A particular focus will be on developing and standardizing protocols for processing samples from preclinical models, such as RNA isolation from diverse tissues, tissue sectioning and staining, immunohistochemistry (IHC) for fibrosis quantification, immunofluorescence (IF), and spatial transcriptomic. This position offers the opportunity to contribute to high-impact research through the generation of high-quality, cost-effective data, and to help drive the success of Haya’s therapeutic pipeline through scientific rigor and operational excellence. What’s in it for me? This opportunity is a launchpad. You’ll have the unique opportunity to deepen your scientific expertise, especially in advanced genomics and lab techniques, while working alongside some of the industry’s most experienced and respected scientists. Whether you're refining your skills in spatial transcriptomics or multi-omics technologies, you’ll be continuously challenged and supported to grow. We are a collective of scientific professionals who thrive on curiosity, collaboration, and the relentless pursuit of progress. We’re committed to making Haya the best place you’ll ever work - where your growth is just as important as our shared mission. We take pride in seeing our colleagues learn, evolve, and reach new levels of professional excellence. You’ll also be based in a newly constructed building designed specifically for science - with brand-new laboratory spaces that promote innovation and efficiency. The campus is equipped with a range of amenities, including a free and impressive gym, on-site restaurants, gardens, and social and collaborative spaces, creating an environment where your work and well-being go hand in hand. You’ll be amazed at what you can accomplish here in a short period of time. This opportunity is only for those who aspire to be on a critical path toward developing a stronger, sharper scientific mind - and you will achieve that at Haya. Key Responsibilities: By now, you probably have a solid idea of what we’re looking for—and what you’ll need to bring to the lab. But here are a few more details to give you a clearer picture of what your day-to-day might look like: Isolation and culture of primary cells or cell lines, such as fibroblasts from various organs, C2C12 cells, myoblasts, and satellite cells from various species, such as human and mouse. Test multiple compounds on primary cells to help us uncover what works (and what doesn’t). Extract RNA, DNA, or proteins from cells and prep them for downstream assays. Precision is key. Generate, analyze, and present data to the R&D team and senior leadership. Your voice will be heard. Maintain a detailed and up-to-date electronic lab notebook; we believe thorough documentation is essential for good science. Support in vivo studies by assisting with sample collection from mouse models, such as skeletal mouse models, including dissection and processing of muscle tissues. You’ll be comfortable working in a vivarium setting and contributing to preclinical research at its source. Work with FFPE (formalin-fixed paraffin-embedded) samples, including sectioning and preparing tissues for downstream analysis. Your attention to detail will make all the difference. Utilize fluorescence microscopy to capture and analyze images from immunofluorescence and spatial transcriptomics experiments. Your keen eye for detail will help transform complex data into valuable scientific insights. Education & Experience: A degree in molecular or cellular biology (or something equivalent that makes you love being in the lab). We appreciate a Master’s degree, but it’s not a dealbreaker. You pick up new techniques fast. You can be absolutely certain this will come up in your interview. Demonstrated expertise in culturing and differentiating various cell types. Bonus points for experience with cell types essential for studying skeletal muscle biology. Experience preparing libraries for a range of next-generation sequencing technologies, like RNA-seq and single-cell sequencing. If you’ve worked on this before, great; if not, but have everything else we’re looking for, we can teach you this. We believe in learning by doing, especially with the support of great mentors. Got experience with RNA biology or fibrosis? That’s a huge plus. Bonus points if you have publications or patents to your name. Tell us about them! HAYA Therapeutics is an Equal Opportunity Employer committed to fostering a diverse, inclusive, and equitable workplace where all individuals feel valued and empowered. We provide equal employment opportunities to all qualified applicants and employees without regard to race, color, religion, sex (including pregnancy, sexual orientation, gender identity, or gender expression), national origin, ancestry, age, marital or familial status, veteran status, disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws. We prohibit discrimination and harassment of any kind and are committed to ensuring fair and equitable treatment in all aspects of recruitment, hiring, promotion, compensation, benefits, training, and career development. At HAYA, we believe that diversity of thought, experience, and background drives innovation and strengthens our mission to transform patient care through cutting-edge RNA-based therapeutics. HAYA Therapeutics is a precision RNA-based therapeutics company that discovers and develops innovative genomic medicines for the treatment of fibrosis and other serious health conditions associated with aging. The company’s discovery engine focuses on long non-coding RNAs (lncRNAs) within the “dark matter” of the human genome -- key tissue and cell-specific drivers of multiple disease processes including fibrosis -- to identify novel targets and drug candidates with the potential for greater efficacy and safety than existing treatments. Headquartered in Lausanne, Switzerland with laboratory facilities in San Diego, USA, HAYA is a rapidly growing company led by a world-class team and supported by a strong investor consortium.

Conditions of employment: Eligible to work in U.S. (U.S. citizenship or work permit/authorization) Doctor of Philosophy Salary range: 140 000 $US - 160 000 $US per year, depending on experience. Why us Be part of a team pioneering cutting-edge research at the forefront of precision medicine Collaborate with a dynamic and innovative team of scientists in a fast-paced biotech environment Competitive benefits package If you believe you are a strong fit for this position, please apply today! To Apply: Please email your CV to E-Mail schreiben and include the position for which you are applying in the subject line. Position Summary HAYA Therapeutics is seeking a talented and experienced Computational Biologist – Single Cell to join our data science team. In this highly collaborative and impactful role, you will lead the analysis of single-cell and single-nuclei transcriptomic and epigenomic datasets to drive target discovery and translational research in the non-coding regulatory genome. You will be the internal expert for single-cell data analysis across diverse tissue types and disease contexts, applying and innovating computational approaches to uncover novel biology and therapeutic opportunities. HAYA deploys a combination of experimental and computational solutions for target and drug discovery in the non-coding regulatory genome space. To this end, we leverage multiple omics modalities, including single-cell and single-nuclei RNA-Seq and ATAC-Seq. You will apply your end-to-end expertise in single-cell and single-nuclei data preprocessing and downstream analysis to contribute to scientific discoveries and the advancement of our precision RNA-based therapeutics for cardiovascular and fibrotic diseases. The analysis templates and approaches to handle complex datasets that you will establish will be used by the entire Data Science team across Haya programs. The Data Science team is central to HAYA’s vision by pioneering innovative AI and advanced computational biology solutions to overcome current scientific, methodological, and operational bottlenecks. We leverage complex biological datasets to remove operator biases, enabling the rapid end-to-end execution of HAYA’s pipeline. Our approach ensures precision-driven decision-making, which enables target drug discovery, biomarkers, translational, clinical, and business strategies, reinforcing HAYA as a leader of next-generation biopharma. What’s in it for me? At HAYA, you won’t just analyze data - you’ll help shape the future of RNA-based therapeutics. This is a unique opportunity to apply your scientific expertise to uncover novel biology in the non-coding regulatory genome and translate those discoveries into real therapeutic potential. You’ll be part of a deeply collaborative and forward-thinking team, working at the intersection of data science, functional genomics, and drug discovery. Here, your insights won’t sit on a shelf - they’ll directly influence the development of treatments for patients with serious cardiovascular and fibrotic diseases. We offer a dynamic, innovative culture where scientific curiosity is celebrated, your voice is heard, and your growth is supported. Whether you're leading high-impact projects, engaging with cross-functional teams, or learning something new every day, you’ll find a meaningful and rewarding career path at HAYA. Key Responsibilities: Act as the internal subject matter expert for single-cell and single-nuclei computational analysis across a variety of tissues and disease models. Develop, implement, and refine advanced computational methodologies to accelerate and enhance the analysis of single-cell datasets. Conduct in-depth investigations using both in-house and publicly available single-cell and epigenomic datasets to uncover disease- and perturbation-specific cell states and regulatory elements, supporting the identification of non-coding RNA targets. Integrate single-cell data with other molecular profiling techniques (e.g., bulk RNA-Seq) to inform biomarker discovery and validation strategies. Prepare and communicate high-quality scientific reports, visualizations, and presentations for both technical and cross-functional stakeholders. Education & Experience: PhD in computational sciences (e.g., bioinformatics, computer science) or life sciences with a strong computational focus, or equivalent industry experience (6+ years). Deep expertise in single-cell and single-nuclei data analysis, including preprocessing, integration, and interpretation of RNA-Seq and ATAC-Seq datasets. Hands-on experience with state-of-the-art computational approaches for single-cell analysis, including ambient RNA correction, cell-type/subtype identification, batch effect correction, and biological interpretation of complex datasets. Proven ability to integrate data from multiple sources to construct clear, biologically meaningful narratives, with a demonstrated track record of delivering high-quality single-cell/nuclei RNA-Seq and ATAC-Seq analysis packages. Proficient in R or Python, with experience working in Linux-based computing environments, including remote server access and basic Bash scripting. Experience with primary epigenomic data analysis (e.g., ATAC-Seq, PRO-Seq, GRO-Seq, CUT&RUN, chromatin conformation capture) to identify functional regions in the regulatory genome is a strong plus. Familiarity with bulk RNA-Seq data analysis is a plus. Excellent written and verbal communication skills in English, with the ability to clearly present complex data to diverse audiences. HAYA Therapeutics is an Equal Opportunity Employer committed to fostering a diverse, inclusive, and equitable workplace where all individuals feel valued and empowered. We provide equal employment opportunities to all qualified applicants and employees without regard to race, color, religion, sex (including pregnancy, sexual orientation, gender identity, or gender expression), national origin, ancestry, age, marital or familial status, veteran status, disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws. We prohibit discrimination and harassment of any kind and are committed to ensuring fair and equitable treatment in all aspects of recruitment, hiring, promotion, compensation, benefits, training, and career development. At HAYA, we believe that diversity of thought, experience, and background drives innovation and strengthens our mission to transform patient care through cutting-edge RNA-based therapeutics. HAYA Therapeutics is a precision RNA-based therapeutics company that discovers and develops innovative genomic medicines for the treatment of fibrosis and other serious health conditions associated with aging. The company’s discovery engine focuses on long non-coding RNAs (lncRNAs) within the “dark matter” of the human genome -- key tissue and cell-specific drivers of multiple disease processes including fibrosis -- to identify novel targets and drug candidates with the potential for greater efficacy and safety than existing treatments. Headquartered in Lausanne, Switzerland with laboratory facilities in San Diego, USA, HAYA is a rapidly growing company led by a world-class team and supported by a strong investor consortium.

Conditions of employment: Eligible to work in U.S. (U.S. citizenship or work permit/authorization) Doctor of Philosophy Salary range: 190 000 $US - 250 000 $US per year, depending on experience. Why us Be part of a team pioneering cutting-edge research at the forefront of precision medicine Collaborate with a dynamic and innovative team of scientists in a fast-paced biotech environment Competitive benefits package If you believe you are a strong fit for this position, please apply today! To Apply: Please email your CV to E-Mail schreiben and include the position for which you are applying in the subject line. Position Summary HAYA Therapeutics is seeking a bold and visionary leader to serve as our Head of Drug Discovery Sciences – a transformative role at the forefront of RNA-based medicine. This is your opportunity to architect and lead a strategically positioned department focused on the design, optimization, and preclinical advancement of next-generation nucleic acid-based therapeutics. This role bridges early target discovery and translational development, ensuring a seamless progression from hit-to-lead through to high-quality development candidates. We’re looking for scientifically rigorous leadership – someone who brings deep expertise in RNA therapeutics, delivery technologies, and, most importantly, effective cross-functional team leadership. You’ll manage a small, high-performing internal team while working in a tight partnership with experts across Data Science, Functional Genomics, and CMC to deliver potent, safe, and scalable therapeutic candidates for clinical development. Your ability to influence and coordinate across disciplines will be critical in driving discovery efforts forward and positioning HAYA for continued growth and innovation. What’s in it for me? Leading HAYA’s Drug Discovery Sciences department, you’ll have a rare opportunity to work with the leadership team to shape the strategy, culture, and scientific direction of a function critical to HAYA’s mission. You’ll be at the forefront of pioneering RNA-based therapeutics, translating breakthrough science into real-world impact for patients with common and chronic diseases. You’ll work alongside a collaborative, deeply knowledgeable team that thrives on intellectual curiosity and scientific rigor. Every day will offer opportunities to learn, grow, and stretch your expertise—whether you're exploring novel delivery platforms, refining candidate selection strategies, or integrating the latest advances in AI, computational biology, and organoid models. This role is designed for those who want to do career-defining work—where your ideas will be heard, your contributions will be valued, and your growth will be supported in an entrepreneurial environment that celebrates innovation and impact. Key Responsibilities: 1. Leadership & Vision Shape and articulate the vision and operational strategy for the Drug Discovery Sciences function with a focus on regulatory genome-targeting RNA therapeutics. Seamlessly integrate chemistry, biology, pharmacology, delivery science, and preclinical development into a unified drug discovery engine. Translate platform innovations and target biology into differentiated therapeutic programs. Optimize resources and budgets while managing vendors and contract research organizations (CROs) in alignment with program goals. Develop and deliver high-impact scientific and strategic summaries for board meetings, investor presentations, and potential financing opportunities, clearly articulating progress, value creation, and scientific differentiation. 2. Candidate Design and Optimization Lead the nomination and optimization of drug candidates, leveraging best-in-class design strategies for stability, potency, and safety. Oversee the integration of novel delivery platforms (e.g., LNPs, conjugates, targeted polymers) in collaboration with formulation experts and translational teams. Drive candidate selection by AI/ML-guided modeling, predictive toxicology, and iterative screening. Drive the generation of robust data packages to support IND-enabling activities and investment decisions. 3. Cross-Functional and Translational Interface Partner closely with Functional Genomics to validate targets and mechanisms of action using genome-scale perturbation data. Partner closely with Data Science to incorporate multi-modal data and computational tools into candidate selection and optimization pipelines. Align with CMC and Translational Sciences to ensure candidates meet regulatory, manufacturability, and scalability criteria from early development. 4. Scientific and Team Leadership Lead and inspire a high-performing multidisciplinary team of scientists across nucleic acid chemistry, delivery, pharmacology, and biology. Foster a high-performance culture of innovation, that thrives on scientific rigor, and collaboration across internal teams and external partners. Monitor trends in RNA therapeutics, delivery, and discovery technologies to ensure HAYA remains at the cutting edge. Qualifications Ph.D. in Molecular Biology, Medicinal Chemistry, Pharmacology, RNA Biology, or a related field; postdoctoral training and industry experience preferred. Minimum of 10 years of experience in RNA biology and therapeutics, with at least 5 years in drug discovery for nucleic acid-based therapeutics in an industry setting. Proven leadership in advancing therapeutic programs from discovery through preclinical development. Strong understanding and background in in non-coding RNA biology Deep understanding of nucleic acid drug modalities, delivery systems, and optimization strategies. Experience managing multidisciplinary teams in a matrix organization and collaborating with external partners, including academia, biotech, and contract research organizations (CROs). Strong knowledge of functional genomics, AI/ML applications, and preclinical development workflows is a significant plus. Excellent leadership, communication, collaboration, and project management skills. HAYA Therapeutics is an Equal Opportunity Employer committed to fostering a diverse, inclusive, and equitable workplace where all individuals feel valued and empowered. We provide equal employment opportunities to all qualified applicants and employees without regard to race, color, religion, sex (including pregnancy, sexual orientation, gender identity, or gender expression), national origin, ancestry, age, marital or familial status, veteran status, disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws. We prohibit discrimination and harassment of any kind and are committed to ensuring fair and equitable treatment in all aspects of recruitment, hiring, promotion, compensation, benefits, training, and career development. At HAYA, we believe that diversity of thought, experience, and background drives innovation and strengthens our mission to transform patient care through cutting-edge RNA-based therapeutics. HAYA Therapeutics is a precision RNA-based therapeutics company that discovers and develops innovative genomic medicines for the treatment of fibrosis and other serious health conditions associated with aging. The company’s discovery engine focuses on long non-coding RNAs (lncRNAs) within the “dark matter” of the human genome -- key tissue and cell-specific drivers of multiple disease processes including fibrosis -- to identify novel targets and drug candidates with the potential for greater efficacy and safety than existing treatments. Headquartered in Lausanne, Switzerland with laboratory facilities in San Diego, USA, HAYA is a rapidly growing company led by a world-class team and supported by a strong investor consortium.

Conditions of employment: Eligible to work in U.S. (U.S. citizenship or work permit/authorization) Salary range: 140 000 $US - 155 000 $US per year, depending on experience. Why us Be part of a team pioneering cutting-edge research at the forefront of precision medicine Collaborate with a dynamic and innovative team of scientists in a fast-paced biotech environment Competitive benefits package If you believe you are a strong fit for this position, please apply today! To Apply: Please email your CV to E-Mail schreiben and include the position for which you are applying in the subject line. Position Summary HAYA Therapeutics seeks an experienced and highly motivated Senior Manager of Clinical Operations to play a critical role in executing our clinical trial for patients with nonobstructive hypertrophic cardiomyopathy (nHCM). In this role, you will provide operational leadership to ensure the successful planning, implementation, and oversight of the clinical trial for our lead asset. The position requires strong organizational skills and the ability to work collaboratively in a fast-paced, growing biotech environment. You will work closely with internal and external stakeholders (including translational development, clinical science, regulatory science, biostatistics and data management, biomarkers, and quality teams) to drive the seamless execution of clinical trials and programs. What’s in it for me? This is a rare opportunity to be the first clinical operations professional at HAYA Therapeutics, where you’ll have the autonomy and influence to help shape the development of a new function from the ground up. You won’t be stepping into a program that’s already in motion; instead, you’ll be joining at the very start of clinical execution and playing a pivotal role in shaping how our trials are conducted. You'll work closely with an experienced and collaborative executive team, including the CMO and Senior Medical Director, and contribute directly to the development of a first-in-class RNA-based therapeutic in cardiology. At HAYA, your work will have an immediate impact on a science-driven, entrepreneurial environment that values initiative, expertise, and innovation. Key Responsibilities: Clinical Trial and Program Leadership: Lead the execution and management of clinical studies and trials, ensuring compliance with regulatory requirements and industry best practices. In addition to HAYA’s initial Phase 1 study for its lead asset, the program is anticipated to transition into Phase 2 and may also involve investigator-initiated studies. Experience managing across a broad range of studies is critical. Responsibilities include active participation in trial design, including drafting and amending clinical trial protocols in close collaboration with the study physician and other cross-functional team members. CRO Management: Participate in the selection process and lead contracting. Oversee and manage relationships with Contract Research Organizations (CROs) and other external vendors to ensure high-quality deliverables, including compliance with protocols, within timelines and budget. Cross-Functional Collaboration: Work closely with internal and external stakeholders, including translational development, clinical science, regulatory science, biostatistics and data management, biomarkers, and quality teams to drive seamless execution of clinical trials and programs. You’ll frequently facilitate clinical operations meetings. Clinical Trial Drug Supply Management: Lead clinical trial drug supply planning and oversight to ensure investigational products are available at sites when needed and in alignment with trial timelines. This includes collaborating with internal teams and external partners to forecast demand, monitor inventory, manage drug shipments, and track returns and accountability. The role requires close coordination with Clinical, CMC, Regulatory, and CRO/vendor teams to proactively identify and mitigate supply risks, ensure compliance with global regulations, and support efficient study execution. Biospecimen Management and Handling: Develop systems for the collection, processing, storage, shipment, and tracking of clinical trial samples. This includes establishing sample management plans, coordinating with sites, labs, and vendors, and ensuring adherence to protocols, chain of custody requirements, and regulatory guidelines. Enrollment Strategy and Monitoring: Collaborate with investigators and cross-functional teams to identify barriers to enrollment and implement targeted strategies to enhance recruitment. Identifying potential challenges in patient recruitment, such as slow enrollment rates, and addressing them proactively. Oversee the preparation of Informed Consent Forms, advertisements, information leaflets, and subject material. Clinical Quality and Regulatory Compliance: Working closely with the Quality colleagues, it is anticipated that the incumbent will implement a robust clinical quality program, which may require authoring essential SOPs and adopting key partner SOPs. Ensure all clinical activities comply with Good Clinical Practice (GCP), International Conference on Harmonization (ICH) guidelines, and applicable regulatory requirements. Safety and Pharmacovigilance: key role in pharmacovigilance activities related to clinical trials. Ensure timely collection, reporting, and analysis of adverse events (AEs), serious adverse events (SAEs), and other safety data throughout the clinical trial process. Develop and maintain safety monitoring plans, risk management plans, and safety surveillance strategies. Collaborating with Clinical Science and CROs to ensure timely data preparation and responses for study-mandated safety review activities. Collaborate with the CRO to ensure compliance with regulatory safety reporting requirements (e.g., ICH E2E, FDA, EMA) and that safety data is accurately conveyed in regulatory submissions and clinical trial reports. Budget & Resource Management: Participate in developing and overseeing clinical study budgets, tracking expenditures, and ensuring cost-effective resource utilization. Provide accurate forecasts and track expenditures to ensure cost-effective management of clinical trials. This individual will also develop systems and procedures and manage aspects of site payment management to ensure timely, accurate, and compliant payments to clinical trial sites in accordance with executed agreements. This includes tracking patient visit payments and milestone-based reimbursements, managing payment schedules, and working closely with Finance, Legal, and CRO partners to ensure transparency and meet mandatory reporting requirements as well as alignment across stakeholders. Site Management and Enrollment Oversight: The Clinical Operations lead serves as the primary point of contact for Study Site Staff and collaborates with the Medical Director and Clinical Project Manager to establish and maintain strong site relationships. The incumbent will be an important member of the site selection team, managing site start-up and ongoing monitoring to ensure efficient patient recruitment and retention. Data Integrity & Reporting: Ensure continuous assessment of data integrity and high-quality clinical trial outcomes. Support the preparation of interim data read outs, clinical trial reports, publications, and presentations for internal and external stakeholders. Qualifications & Experience Bachelor’s or Master’s degree in life sciences, health sciences, or a related field. 8+ years of experience in clinical operations, with a proven track record in leading and managing multiple clinical trials from initiation to completion. Strong knowledge of global clinical development processes, regulatory guidelines (including FDA, EMA, and ICH-GCP), and clinical trial design and execution. Experience in managing external vendors, particularly contract research organizations (CROs). Expertise in developing and managing clinical study budgets and timelines. Excellent communication, presentation, and negotiation skills with the ability to foster a collaborative team environment. High degree of adaptability and problem-solving skills in a dynamic biotech environment. Experience in RNA-based therapeutics, cardiology, rare disease, or related fields is a plus. Ability to travel up to 50% as required for clinical trial oversight and site visits. HAYA Therapeutics is a precision RNA-based therapeutics company that discovers and develops innovative genomic medicines for the treatment of fibrosis and other serious health conditions associated with aging. The company’s discovery engine focuses on long non-coding RNAs (lncRNAs) within the “dark matter” of the human genome -- key tissue and cell-specific drivers of multiple disease processes including fibrosis -- to identify novel targets and drug candidates with the potential for greater efficacy and safety than existing treatments. Headquartered in Lausanne, Switzerland with laboratory facilities in San Diego, USA, HAYA is a rapidly growing company led by a world-class team and supported by a strong investor consortium.

Conditions of employment: Eligible to work in U.S. (U.S. citizenship or work permit/authorization) Doctor of Philosophy Salary range: 130 000 $US - 155 000 $US per year, depending on experience. Why us Be part of a team pioneering cutting-edge research at the forefront of precision medicine Collaborate with a dynamic and innovative team of scientists in a fast-paced biotech environment Competitive benefits package If you believe you are a strong fit for this position, please apply today! To Apply: Please email your CV to E-Mail schreiben and include the position for which you are applying in the subject line. Position Summary The Drug Discovery Sciences (DDS) Department is seeking an exceptional and visionary Senior or Principal Scientist to play a key leadership role in the discovery and optimization of nucleic acid-based therapeutics, with a focus on RNA modalities and their targeted delivery. Reporting directly to the Head of DDS, this role will be instrumental in translating cutting-edge science into transformative therapeutic candidates that bridge the gap from early discovery to preclinical proof-of-concept and IND-enabling readiness. As a core scientific contributor and strategic driver within DDS, you will lead efforts to refine RNA chemistry, optimize delivery systems, and integrate early translational considerations to enhance the potency, safety, manufacturability, and clinical translatability of RNA therapeutic candidates. Your work will directly support DDS’s mission to serve as the translational engine of the R&D organization—positioned between Target Discovery and Development—and will contribute to building a sustainable and innovative pipeline of precision medicines. You will leverage your deep expertise in RNA biology, drug delivery technologies, computational design, and mechanistic pharmacology to guide molecule and formulation optimization. This includes driving the application of AI/ML tools, high-throughput screening platforms, and mechanism-driven assay systems, including organoid and organ-on-chip models, to validate candidate function and safety. You will lead matrixed project teams, collaborate extensively across departments, and integrate scientific innovations emerging from Data Science, Functional Genomics, CMC, and other core disciplines. In this highly interdisciplinary environment, you will play a pivotal role in shaping and executing strategies for nucleic acid therapeutic development, contribute to platform build-out efforts, and help establish best practices for candidate nomination and progression. The ideal candidate is a scientific leader and team player who thrives at the interface of innovation and application and is motivated to make a meaningful impact on patient outcomes through next-generation therapies. In addition to executing on the strategic vision of DDS and providing scientific leadership, this role requires a strong commitment to hands-on science, with approximately 30–40% of time (1.5–2 days per week) dedicated to designing and executing key experiments. What’s in it for me? As an early member of the newly established Drug Discovery Sciences department, you’ll have a rare opportunity to work with the leadership team to shape the strategy, culture, and scientific direction of a function critical to HAYA’s mission. You’ll be at the forefront of pioneering RNA-based therapeutics, translating breakthrough science into real-world impact for patients with common and chronic diseases. You’ll work alongside a collaborative, deeply knowledgeable team that thrives on intellectual curiosity and scientific rigor. Every day will offer opportunities to learn, grow, and stretch your expertise—whether you're exploring novel delivery platforms, refining candidate selection strategies, or integrating the latest advances in AI, computational biology, and organoid models. This role is designed for those who want to do career-defining work—where your ideas will be heard, your contributions will be valued, and your growth will be supported in an entrepreneurial environment that celebrates innovation and impact. Key Responsibilities: Therapeutic Optimization Design and refine next-generation nucleic acid therapeutics optimized for potency, specificity, safety and stability. Lead high-throughput screening (HTS) campaigns to explore sequence-structure relationships and chemistry modifications. Assess off-target effects and immunogenicity to de-risk candidates pre-clinically. Develop and apply mechanism-based assay cascades in physiologically relevant systems (e.g., organoids, organ-on-a-chip) Delivery Technologies and Platform Innovation Design and validate novel delivery platforms (e.g., lipid nanoparticles, conjugates, polymers) for targeted biodistribution, intracellular delivery, and endosomal escape. Integrate computational modeling with wet-lab validation for rational delivery system design Collaborate with CMC and formulation teams to ensure scalability, stability, and regulatory readiness of delivery technologies. Candidate Screening and Nomination Develop and implement programs that de-risk in vivo studies Incorporate biomarker strategies and in vivo safety data into candidate nomination workflows. Use patient-derived models for functional validation and PD readouts Partner with the Functional Genomics team to assess gene regulation and cell-state reprogramming. Contribute to the standardization of data generation aligned with IND-enabling study requirements Cross-Functional Integration and Leadership Interface with Data Science to implement and integrate AI/ML-powered pipelines, design, and prediction tools. Collaborate with Functional Genomics to validate target engagement, drug response, and mechanism of action Serve as a scientific thought leader across multidisciplinary project teams to accelerate candidate selection and optimization. Contribute to strategic planning and resource allocation within DDS and the broader R&D function. Education & Experience: PhD in Molecular Biology, Biochemistry, Chemical Biology, Pharmaceutical Sciences, or related field. 10+ years of experience in nucleic acid therapeutics, drug discovery, or translational research, preferably with several years in an industry setting. Proven track record of designing and advancing RNA-based therapeutics. Strong knowledge of delivery technologies including nanoparticles (LNPs, PNPs), conjugation strategies (small-molecules, peptides, antibodies, and other biomolecules). Experience with high-throughput assays, screening platforms, and biomarker discovery. Familiarity with computational approaches to sequence and structural optimization is a plus. Demonstrated ability to lead scientific teams and collaborate across functions. HAYA Therapeutics is an Equal Opportunity Employer committed to fostering a diverse, inclusive, and equitable workplace where all individuals feel valued and empowered. We provide equal employment opportunities to all qualified applicants and employees without regard to race, color, religion, sex (including pregnancy, sexual orientation, gender identity, or gender expression), national origin, ancestry, age, marital or familial status, veteran status, disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws. We prohibit discrimination and harassment of any kind and are committed to ensuring fair and equitable treatment in all aspects of recruitment, hiring, promotion, compensation, benefits, training, and career development. At HAYA, we believe that diversity of thought, experience, and background drives innovation and strengthens our mission to transform patient care through cutting-edge RNA-based therapeutics. HAYA Therapeutics is a precision RNA-based therapeutics company that discovers and develops innovative genomic medicines for the treatment of fibrosis and other serious health conditions associated with aging. The company’s discovery engine focuses on long non-coding RNAs (lncRNAs) within the “dark matter” of the human genome -- key tissue and cell-specific drivers of multiple disease processes including fibrosis -- to identify novel targets and drug candidates with the potential for greater efficacy and safety than existing treatments. Headquartered in Lausanne, Switzerland with laboratory facilities in San Diego, USA, HAYA is a rapidly growing company led by a world-class team and supported by a strong investor consortium.